Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Serum levels of autoantibodies against C-reactive protein correlate with renal disease activity and response to therapy in lupus nephritis. | Available online http content 11 6 R188 Research article Serum levels of autoantibodies against C-reactive protein correlate with renal disease activity and response to therapy in lupus nephritis Christopher Sjowall1 Agneta Zickert2 Thomas Skogh1 Jonas Wettero1 and Iva Gunnarsson2 1Rheumatology AIR Clinical and Experimental Medicine Linkoping University SE-581 85 Linkoping Sweden 2Department of Medicine Rheumatology Unit Karolinska University Hospital Solna SE-171 76 Stockholm Sweden Corresponding author Christopher Sjowall Received 2 Aug 2009 Revisions requested 26 Aug 2009 Revisions received 3 Dec 2009 Accepted 11 Dec 2009 Published 11 Dec 2009 Arthritis Research Therapy 2009 11 R188 doi 86 ar2880 This article is online at http content 11 6 R188 2009 Sjowall et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Serum levels of C-reactive protein CRP seldom reflect disease activity in systemic lupus erythematosus SLE . We have previously shown that autoantibodies against neoepitopes of CRP often occur in SLE but that this does not explain the modest CRP response seen in flares. However we have repeatedly found that anti-CRP levels parallel lupus disease activity with highest levels in patients with renal involvement thus we aimed to study anti-CRP in a material of well-characterized lupus nephritis patients. Methods Thirty-eight patients with lupus nephritis were included. Treatment with corticosteroids combined with cyclophosphamide mycophenolate mofetil or rituximab was started after baseline kidney biopsy. A second biopsy was taken after 6 months. Serum creatinine cystatin C complement anti-dsDNA anti-CRP .
