Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Immunoglobulin G galactosylation and sialylation are associated with pregnancy-induced improvement of rheumatoid arthritis and the postpartum flare: results from a large prospective cohort study. | Available online http content 11 6 R193 Open Access Research article Immunoglobulin G galactosylation and sialylation are associated with pregnancy-induced improvement of rheumatoid arthritis and the postpartum flare results from a large prospective cohort study Fleur E van de Geijn1 Manfred Wuhrer2 Maurice HJ Selman2 Sten P Willemsen3 Yael A de Man1 André M Deelder2 Johanna MW Hazes1 and Radboud JEM Dolhain1 Department of Rheumatology Erasmus MC University Medical Center Rotterdam Dr. Molewaterplein 50 3015 GE Rotterdam The Netherlands 2Biomolecular Mass Spectrometry Unit Department of Parasitology Leiden University Medical Center Albinusdreef 2 PB 9503 Leiden The Netherlands 3Department of Biostatistics Erasmus MC University Medical Center Rotterdam Dr. Molewaterplein 50 3015 GE Rotterdam The Netherlands Corresponding author Fleur E van de Geijn Received 21 Sep 2009 Revisions requested 3 Nov 2009 Revisions received 1 Dec 2009 Accepted 16 Dec 2009 Published 16 Dec 2009 Arthritis Research Therapy 2009 11 R193 doi 86 ar2892 This article is online at http content 11 6 R193 2009 van de Geijn et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Improvement of rheumatoid arthritis RA during pregnancy has been causatively associated with increased galactosylation of immunoglobulin G IgG N-glycans. Since previous studies were small did not include the postpartum flare and did not study sialylation these issues were addressed in the present study. Methods Serum from 148 RA cases and 32 healthy controls was collected at several time points before during and after pregnancy. Improvement during pregnancy and postpartum flare were .
