Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: Mutations that permit residual CFTR function delay acquisition of multiple respiratory pathogens in CF patients. | Green et al. Respiratory Research 2010 11 140 http content 11 1 140 RESPIRATORY RESEARCH RESEARCH Open Access Mutations that permit residual CFTR function delay acquisition of multiple respiratory pathogens in CF patients I 1S-. s u . u . s ft I f _Vr 1 Ì I V ĩc h K r fs I Iz-i I 2 c h ỉ o I fl m 3 4 D xtrl z s D Cz i r - 3 I I I r - ĩ D I_l x srr s 3 Deanna M Green Kathryn E McDougal Scott M BlacKman Patrick R sosnay Lindsay B Henderson Kathleen M Naughton3 J Michael Collaco1 Garry R Cutting3 Abstract Background Lung infection by various organisms is a characteristic feature of cystic fibrosis CF . CFTR genotype effects acquisition of Pseudomonas aeruginosa Pa however the effect on acquisition of other infectious organisms that frequently precede Pa is relatively unknown. Understanding the role of CFTR in the acquisition of organisms first detected in patients may help guide symptomatic and molecular-based treatment for CF. Methods Lung infection defined as a single positive respiratory tract culture was assessed for 13 organisms in 1 381 individuals with CF. Subjects were divided by predicted CFTR function Residual carrying at least one partial function CFTR mutation class IV or V and Minimal those who do not carry a partial function mutation. Kaplan-Meier estimates were created to assess CFTR effect on age of acquisition for each organism. Cox proportional hazard models were performed to control for possible cofactors. A separate Cox regression was used to determine whether defining infection with Pa mucoid Pa or Aspergillus Asp using alternative criteria affected the results. The influence of severity of lung disease at the time of acquisition was evaluated using stratified Cox regression methods by lung disease categories. Results Subjects with Minimal CFTR function had a higher hazard than patients with Residual function for acquisition of 9 of 13 organisms studied HR ranging from to based on the organism studied . Subjects .
