Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" Peripheral endothelial dysfunction is associated with gas exchange inefficiency in smokers. | Glăser et al. Respiratory Research 2011 12 53 http content 12 1 53 RESPIRATORY RESEARCH RESEARCH Open Access Peripheral endothelial dysfunction is associated with gas exchange inefficiency in smokers 1 1 13 1 112 Sven Glaser Anne Obst Christian F Opitz Marcus Dorr Stephan B Felix Klaus Empen Henry Volzke Ralf Ewert1 Christoph Schaper1 and Beate Koch1 Abstract Aims To assess the cross-sectional association between exercise capacity gas exchange efficiency and endothelial function as measured by flow-mediated dilation FMD and nitroglycerin-mediated dilation NMD of the brachial artery in a large-scale population-based survey. Methods The study population was comprised of 1416 volunteers 25 to 85 years old. Oxygen uptake at anaerobic threshold VO2@AT peak exercise peakVO2 and ventilatory efficiency VE vs. VCO2 slope and VE VCO2@AT were assessed on a breath-by-breath basis during incremental symptom-limited cardiopulmonary exercise. FMD and NMD measurements at rest were performed using standardised ultrasound techniques. Results Multivariable logistic regression analyses revealed a significant association between FMD and ventilatory efficiency in current smokers but not in ex-smokers or non-smokers. There was no association between FMD and VO2@AT or peak VO2. In current smokers for each one millimetre decrement in FMD VE VCO2@AT improved by 95 CI in the overall population VE vs. VCO2 slope . These results remained robust after adjusting for all major influencing factors. Neither exercise capacity nor ventilatory efficiency was significantly associated with NMD. Conclusion In current smokers FMD is significantly associated with ventilatory efficiency. This result may be interpreted as a potential clinical link between smoking and early pulmonary vasculopathy due to smoking. Introduction Endothelial dysfunction represents an early subclinical stage of vascular dysfunction that precedes the development of .
