Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" Exhaled breath condensate pH as a biomarker of COPD severity in ex-smokers. | Papaioannou et al. Respiratory Research 2011 12 67 http content 12 1 67 RESPIRATORY RESEARCH RESEARCH Open Access Exhaled breath condensate pH as a biomarker of COPD severity in ex-smokers Andriana I Papaioannou1 Stelios Loukides2 Markos Minas1 Konstantina Kontogianni3 Petros Bakakos3 1 3 r- n 2 Konstantinos I Gourgoulianis Manos Alchanatis Spyros Papiris and Konstantinos Kostikas Abstract Endogenous airway acidification as assessed by exhaled breath condensate EBC pH is present in patients with stable COPD. The aim of this study was to measure EBC pH levels in a large cohort of COPD patients and to evaluate associations with functional parameters according to their smoking status. EBC was collected from 161 patients with stable COPD and 112 controls current and ex-smokers . EBC pH was measured after Argon deaeration and all subjects underwent pulmonary function testing. EBC pH was lower in COPD patients compared to controls vs. p and exsmokers with COPD had lower EBC pH compared to current smokers vs p . In ex-smokers with COPD EBC pH was lower in patients with GOLD stage III and IV compared to patients with stage I disease p and respectively . No differences were observed among current smokers with different disease severity. EBC pH levels in ex-smokers were associated with static hyperinflation as expressed by IC TLC ratio air trapping as expressed by RV TLC ratio and diffusing capacity for carbon monoxide whereas no associations were observed in current smokers. Endogenous airway acidification is related to disease severity and to parameters expressing hyperinflation and air trapping in ex-smokers with COPD. The possible role of EBC pH in COPD needs to be further evaluated in longitudinal studies. Introduction Chronic obstructive pulmonary disease COPD is characterized by airflow limitation that is not fully reversible is usually progressive and is .
