Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: The value of ultrasonography in predicting arthritis in auto-antibody positive arthralgia patients: a prospective cohort study. | van de Stadt et al. Arthritis Research Therapy 2010 12 R98 http content 12 3 R98 RESEARCH ARTICLE Open Access The value of ultrasonography in predicting arthritis in auto-antibody positive arthralgia patients a prospective cohort study Lotte A van de Stadt 1 Wouter H Bos1 Marlies Meursinge Reynders2 Helen Wieringa2 Franktien Turkstra1 Conny J van der Laken1 3 and Dirkjan van Schaardenburg1 3 Abstract Introduction Ultrasonography US has better sensitivity than clinical evaluation for the detection of synovitis in early rheumatoid arthritis RA . Patients presenting with arthralgia and a positive anti-citrullinated protein antibodies ACPA and or Rheumatoid Factor IgM-RF status are at risk for developing RA. In the present study US utility and predictive properties in arthralgia patients at risk for the development of arthritis were studied. Methods 192 arthralgia patients with ACPA and or IgM-RF were included. Absence of clinical arthritis was confirmed by two physicians. US was performed by one of two trained radiologists of any painful joint and of adjacent and contralateral joints. Joint effusion synovitis and power Doppler PD signal in the synovial membrane of the joints and tenosynovitis adjacent to the joint were evaluated and classified on a 4-grade semi-quantitative scale. Grade 2-3 joint effusion synovitis tenosynovitis and grade 1-3 Power Doppler signal were classified as abnormal. Results Forty-five patients 23 developed arthritis after a mean of 11 months. Inter-observer reliability for synovitis and PD was moderate kappa and respectively and for joint effusion low kappa . The prevalence of tenosynovitis was too low to calculate representative kappa values. At joint level a significant association was found between US abnormalities and arthritis development in that joint for joint effusion synovitis and PD. At patient level a trend was seen towards more arthritis development in patients who had US abnormalities for .
