Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Synthesis of tenascin and laminin beta2 chain in human bronchial epithelial cells is enhanced by cysteinyl. | Respiratory Research BioMed Central Research Synthesis of tenascin and laminin beta2 chain in human bronchial epithelial cells is enhanced by cysteinyl leukotrienes via CysLT 1 receptor Siiri Altraja1 2 Martin Kadai3 Erki Rekker4 and Alan Altraja 4 Address institute of General Molecular Pathology University of Tartu Tartu Estonia 2Estonian Biocentre Tartu Estonia institute of Molecular Cell Biology University of Tartu Tartu Estonia and 4Department of Pulmonary Medicine University of Tartu Tartu Estonia Email Siiri Altraja - Martin Kadai - kada@ Erki Rekker - erx@ Alan Altraja - alan@ Corresponding author Open Access Published 26 May 2008 Received 10 November 2007 Respiratory Research 2008 9 44 doi 1465-9921 -9-44 Accepted 26 May 2008 This article is available from http content 9 1 44 2008 Altraja et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Cysteinyl leukotrienes CysLTs are key mediators of asthma but their role in the genesis of airway remodeling is insufficiently understood. Recent evidence suggests that increased expression of tenascin Tn and laminin Ln P2 chain is indicative of the remodeling activity in asthma but represents also an example of deposition of extracellular matrix which affects the airway wall compliance. We tested the hypothesis that CysLTs affect production of Tn and Ln P2 chain by human bronchial epithelial cells and elucidated which of the CysLT receptors CysLT1 or CysLT2 mediate this effect. Methods Cultured BEAS-2B human bronchial epithelial cells were stimulated with leukotriene D4 LTD4 and E4 LTE4 and evaluated .
