Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Associations between the HLA-A polymorphism and the clinical manifestations of Behcet’s disease. | Kang et al. Arthritis Research Therapy 2011 13 R49 http content 13 2 R49 RESEARCH ARTICLE Open Access Associations between the HLA-A polymorphism and the clinical manifestations of Behcet s disease 1 2 3 2 2 2 1 Eun Ha Kang Jeong Yeon Kim Fujio Takeuchi Joon Wan Kim Kichul Shin Eun Young Lee Yun Jong Lee Eun Bong Lee2 4 Myoung Hee Park4 5 and Yeong Wook Song2 4 Abstract Introduction The objective was to investigate associations between the HLA-A gene and Behcet s disease BD and its clinical manifestations. Methods Genotyping for the HLA-A locus was performed using the polymerase chain reaction-Luminex typing method in 223 BD patients and 1 398 healthy controls. Results The phenotypic frequencies of HLA-A 02 07 odds ratio OR P A 26 01 OR P and A 30 04 OR P tended to be higher in BD patients than in normal controls but the frequency of A 33 03 OR P tended to be lower in BD patients. A meta-analysis adopting our and the Japanese data confirmed the associations of HLA-A 02 07 A 26 01 and A 33 03 with BD. Furthermore the frequencies of the HLA-A 02 07 A 26 01 and A 30 04 were significantly higher in patients with skin lesions OR P Pc and arthritis OR P Pc with uveitis OR P Pc and with vascular lesions OR P Pc and a positive pathergy test OR P Pc respectively than in controls. In HLA-B 51 non-carriers these associations were also significant being much stronger between HLA-A 26 01 and uveitis OR P Pc and between HLA-A 30 04 and vascular lesions OR P Pc . In addition HLA-A 30 04 was associated with genital ulcers in HLA-B 51 non-carriers OR P Pc . Conclusions HLA-A 02 07 A 26 01 and A 30 04 were associated with increased risk for BD while HLA-A 33 03 with decreased risk. HLA-A 02 07 A 26 01 and A 30 04 were associated with skin lesions and arthritis with uveitis .
