Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:"Intravenous administration of activated protein C in Pseudomonas-induced lung injury: impact on lung fluid balance and the inflammatory response. | Respiratory Research BioMed Central Research Open Access Intravenous administration of activated protein C in Pseudomonas-induced lung injury impact on lung fluid balance and the inflammatory response Laurent Robriquet1 Francois Collet1 Antoine Tournoys2 Thierry Prangère3 Rémi Nevière1 Francois Fourrier1 and Benoit P Guery 1 Address 1EA 2689 Faculté de Médecine-Université de Lille 2- 1 place de Verdun 59045 Lille Cedex France 2Laboratoire d Hématologie CHRU Lille Hopital Salengro Bd Pr Leclecq 59037 Lille Cedex France and 3Laboratoire de Biophysique- Service de Médecine Nucléaire-Faculté de Médecine CHRU de Lille- 1 place de Verdun 59045 Lille Cedex France Email Laurent Robriquet - l-robriquet@ Francois Collet - francoiscollet@ Antoine Tournoys - a-tournoys@ Thierry Prangère - t-prangere@ Rémi Nevière - r-neviere@ Francois Fourrier - f-fourrier@ Benoit P Guery - bguery@ Corresponding author Published 22 March 2006 Received 03 January 2006 Respiratory Research2006 7 41 doi 1465-9921-7-41 Accepted 22 March 2006 This article is available from http content 7 1 41 2006Robriquet et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Acute lung injury ALI induces a coagulation fibrinolysis imbalance and leads to fibrin deposition. The protein C pathway is an important regulator of the coagulation system and reduces the inflammatory response. The aim of the study was to examine the effects of recombinant human activated protein C rhAPC in the early phase of Pseudomonas aeruginosa Pa -induced lung injury. Methods The study was conducted in vivo on a rat model of Pa-induced ALI. Continuous .
