Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" Expression of Toll-like receptor 2 is up-regulated in monocytes from patients with chronic obstructive pulmonary disease. | Respiratory Research BioMed Central Research Open Access Expression of Toll-like receptor 2 is up-regulated in monocytes from patients with chronic obstructive pulmonary disease Jaume Pons1 4 Jaume Sauleda3 Veronica Regueiro2 Carmen Santos1 Meritxell Lopez3 Joana Ferrer4 Alvar GN Agustí2 3 and José A Bengoechea 1 2 Address 1Unidad de Investigación Hospital Son Dureta Institut Universitari d Investigacions en Ciències de la Salut IUNICS Palma Mallorca Spain 2Program Infection and Immunity Fundacio Caubet-CIMERA Illes Balears Bunyola Spain 3Servicio de Neumología Hospital Son Dureta Palma Mallorca Spain and 4Servicio de Inmunología Hospital Son Dureta Palma Mallorca Spain Email Jaume Pons - jpons@ Jaume Sauleda - jsauleda@ Veronica Regueiro - veroregueiro@ Carmen Santos - csantos@ Meritxell Lopez - mlopez@ Joana Ferrer - jferrer@ Alvar GN Agustí - aagusti@ José A Bengoechea - bengoechea@ Corresponding author Published 10 April 2006 Received 06 October 2005 Respiratory Research2006 7 64 doi 1465-9921 -7-64 Accepted 10 April 2006 This article is available from http content 7 1 64 2006Pons et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Chronic obstructive pulmonary disease COPD is characterised by pulmonary and systemic inflammation which flare-up during episodes of acute exacerbation AECOPD . Given the role of Toll-like receptors TLRs in the induction of inflammatory responses we investigated the involvement of TLRs in COPD pathogenesis. Methods The expression of TLR-2 TLR-4 and CD 14 in monocytes was analyzed by flow cytometry. To study the functional responses of these receptors monocytes were stimulated
