Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:Thiolated chitosan nanoparticles enhance anti-inflammatory effects of intranasally delivered theophylline. | Respiratory Research BioMed Central Research Open Access Thiolated chitosan nanoparticles enhance anti-inflammatory effects of intranasally delivered theophylline Dong-Won Lee Shawna A Shirley Richard F Lockey and Shyam S Mohapatra Address Division of Allergy and Immunology and Joy McCann Culverhouse Airway Disease Center Department of Internal Medicine University of South Florida College of Medicine and James A. Haley Veteran s Hospital Tampa FL 33612 USA Email Dong-Won Lee - dlee@ Shawna A Shirley - sshirley@ Richard F Lockey - rlockey@ Shyam S Mohapatra - smohapat@ Corresponding author Published 24 August 2006 Received 25 April 2006 Respiratory Research 2006 7 112 doi 1465-9921-7-112 Accepted 24 August 2006 This article is available from http content 7 1 1 12 2006 Lee et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Chitosan a polymer derived from chitin has been used for nasal drug delivery because of its biocompatibility biodegradability and bioadhesiveness. Theophylline is a drug that reduces the inflammatory effects of allergic asthma but is difficult to administer at an appropriate dosage without causing adverse side effects. It was hypothesized that adsorption of theophylline to chitosan nanoparticles modified by the addition of thiol groups would improve theophylline absorption by the bronchial epithelium and enhance its anti-inflammatory effects. Objectives We sought to develop an improved drug-delivery matrix for theophylline based on thiolated chitosan and to investigate whether thiolated chitosan nanoparticles TCNs can enhance theophylline s capacity to alleviate allergic asthma. Methods A mouse model of .
