Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:: " Clinical implications for Vascular Endothelial Growth Factor in the lung: friend or foe. | Respiratory Research BioMed Central Open Access Review Clinical implications for Vascular Endothelial Growth Factor in the lung friend or foe Andriana I Papaioannou1 Konstantinos Kostikas1 Panagoula Kollia2 and Konstantinos I Gourgoulianis 1 Address Respiratory Medicine Department University of Thessaly School of Medicine University Hospital of Larissa Larissa 41110 Greece and 2Biology Department University of Thessaly School of Medicine University Hospital of Larissa Larissa 41110 Greece Email Andriana I Papaioannou - andriana78@ Konstantinos Kostikas - ktk@ Panagoula Kollia - kollia@ Konstantinos I Gourgoulianis - kgourg@ Corresponding author Published 17 October 2006 Received 21 June 2006 Respiratory Research 2006 7 128 doi 1465-9921-7-128 Accepted 17 October 2006 This article is available from http content 7 l l28 2006 Papaioannou et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Vascular endothelial growth factor VEGF is a potent mediator of angiogenesis which has multiple effects in lung development and physiology. VEGF is expressed in several parts of the lung and the pleura while it has been shown that changes in its expression play a significant role in the pathophysiology of some of the most common respiratory disorders such as acute lung injury asthma chronic obstructive pulmonary disease obstructive sleep apnea idiopathic pulmonary fibrosis pulmonary hypertension pleural disease and lung cancer. However the exact role of VEGF in the lung is not clear yet as there is contradictory evidence that suggests either a protective or a harmful role. VEGF seems to interfere in a different manner depending on its amount the location and
