Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: The effects of IgM-enriched immunoglobulin preparations in patients with severe sepsis [ISRCTN28863830]. | Available online http content 6 4 357 Research The effects of IgM-enriched immunoglobulin preparations in patients with severe sepsis ISRCTN28863830 Simru Tugrul1 Perihan Ergin Ozcan1 Ozkan Akinci1 Yalcin Seyhun2 Atahan Cagatay3 Nahit Cakar4 and Figen Esen4 Registrar Anesthesiology Department Medical Faculty Istanbul University Turkey 2Registrar Medical Biology Department Medical Faculty Istanbul University Turkey 3Registrar Clinical Bacteriology and Infectious Diseases Department Medical Faculty Istanbul University Turkey 4Consultant Anesthesiology Department Medical Faculty Istanbul University Turkey Correspondence Simru Tugrul mtugrul@ Received 7 December 2001 Revisions requested 14 March 2002 Revisions received 9 April 2002 Accepted 19 April 2002 Published 14 May 2002 Critical Care 2002 6 357-362 This article is online at http content 6 4 357 2002 Tugrul et al. licensee BioMed Central Ltd Print ISSN 1364-8535 Online ISSN 1466-609X Abstract Introduction In this prospective randomized controlled study we aimed to evaluate the effect of IgM-enriched immunoglobulin treatment on progression of organ failure and septic shock in patients with severe sepsis. Materials and methods Forty-two patients with severe sepsis were enrolled in the study. Patients in the study group n 21 received an intravenous immunoglobulin preparation Pentaglobin in addition to standard therapy. Pentaglobin therapy was commenced on the day of diagnosis of severe sepsis 5 ml kg per day Pentaglobin 38 g l IgG 6 g l IgM and 6 g l IgA was infused over 6 hours and repeated for 3 consecutive days. Patients in the control group n 18 received standard sepsis therapy but no immunoglobulin administration. Blood samples for procalcitonin PCT measurements were taken daily for 8 days. Severity of critical illness and development of organ failure were assessed by obtaining daily acute physiological and chronic health evaluation APACHE II and sequential organ failure .
