Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:way epithelial cell tolerance to Pseudomonas aeruginosa. | Respiratory Research BioMed Central Research Airway epithelial cell tolerance to Pseudomonas aeruginosa Qi Wu1 Zhong Lu1 Margrith W Verghese1 and Scott H Randell 1 2 Open Access Address 1Cystic Fibrosis Pulmonary Research and Treatment Center Department of Medicine The University of North Carolina Chapel Hill NC 27599 USA and 2Department of Cellular and Molecular Physiology The University of North Carolina Chapel Hill NC 27599 USA Email Qi Wu - liaohw66@ Zhong Lu - zhong_lu@ Margrith W Verghese - Scott H Randell - randell@ Corresponding author Published 01 April 2005 Received 21 December 2004 Respiratory Research 2005 6 26 doi 1465-9921 -6-26 Accepted 01 April 2005 This article is available from http content 6 1 26 2005 Wu et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The respiratory tract epithelium is a critical environmental interface that regulates inflammation. In chronic infectious airway diseases pathogens may permanently colonize normally sterile luminal environments. Host-pathogen interactions determine the intensity of inflammation and thus rates of tissue injury. Although many cells become refractory to stimulation by pathogen products it is unknown whether the airway epithelium becomes either tolerant or hypersensitive in the setting of chronic infection. Our goals were to characterize the response of well-differentiated primary human tracheobronchial epithelial cells to Pseudomonas aeruginosa to understand whether repeated exposure induced tolerance and if so to explore the mechanism s . Methods The apical surface of well-differentiated primary human tracheobronchial epithelial cell cultures .
