Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Retrovirology Research cung cấp cho các bạn kiến thức về ngành y đề tài:"Discovery of novel targets for multi-epitope vaccines: Screening of HIV-1 genomes using association rule mining. | Retrovirology BioMed Central Research Discovery of novel targets for multi-epitope vaccines Screening of HIV-1 genomes using association rule mining Sinu Paul and Helen Piontkivska Open Access Address Department of Biological Sciences Kent State University Kent Ohio 44242 USA Email Sinu Paul - spaul1@ Helen Piontkivska - opiontki@ Corresponding author Published 6 July 2009 Received 14 April 2009 Retrovirology 2009 6 62 doi 1742-4690-6-62 Accepted 6 July 2009 This article is available from http content 6 1 62 2009 Paul and Piontkivska licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Studies have shown that in the genome of human immunodeficiency virus HIV-1 regions responsible for interactions with the host s immune system namely cytotoxic T-lymphocyte CTL epitopes tend to cluster together in relatively conserved regions. On the other hand epitope-less regions or regions with relatively low density of epitopes tend to be more variable. However very little is known about relationships among epitopes from different genes in other words whether particular epitopes from different genes would occur together in the same viral genome. To identify CTL epitopes in different genes that co-occur in HIV genomes association rule mining was used. Results Using a set of 189 best-defined HIV-1 CTL CD8 epitopes from 9 different proteincoding genes as described by Frahm Linde Brander 2007 we examined the complete genomic sequences of 62 reference HIV sequences including 13 subtypes and sub-subtypes with approximately 4 representative sequences for each subtype or sub-subtype and 18 circulating recombinant forms . The results showed that despite inclusion of recombinant sequences
