Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Retrovirology cung cấp cho các bạn kiến thức về ngành y đề tài: " Mechanism of HIV-1 Tat RNA translation and its activation by the Tat protein. | Retrovirology BioMed Central Open Access Mechanism of HIV-1 Tat RNA translation and its activation by the Tat protein Nicolas Charnay1 Roland Ivanyi-Nagy1 Ricardo Soto-Rifo2 Théophile Ohlmann2 Marcelo López-Lastra3 and Jean-Luc Darlix 1 Address 1LaboRetro Unité de Virologie Humaine INSERM 758 IFR 128 ENS de Lyon 46 allée d Italie 69364 Lyon France 2TEV Unité de Virologie Humaine INSERM 758 IFR 128 ENS de Lyon 46 allée d Italie 69364 Lyon France and 3Laboratorio de Virología Molecular Centro de Investigaciones Médicas Facultad de Medicina Pontificia Universidad Católica de Chile Marcoleta 391 Santiago Chile Email Nicolas Charnay - charnaynicolas@ Roland Ivanyi-Nagy - Ricardo Soto- Rifo - Théophile Ohlmann - tohlmann@ Marcelo López-Lastra - malopez@ Jean- Luc Darlix - jldarlix@ Corresponding author Published II August 2009 Received 4 March 2009 Accepted 1 1 August 2009 Retrovirology 2009 6 74 doi 1742-4690-6-74 This article is available from http content 6 1 74 2009 Charnay et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The human immunodeficiency virus type 1 HIV-1 Tat protein is a major viral transactivator required for HIV-1 replication. In the nucleus Tat greatly stimulates the synthesis of full-length transcripts from the HIV-1 promoter by causing efficient transcriptional elongation. Tat induces elongation by directly interacting with the bulge of the transactivation response TAR RNA a hairpin-loop located at the 5 -end of all nascent viral transcripts and by recruiting cellular transcriptional co-activators. In the cytoplasm Tat is thought to act as a .
