Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " HTLV-1 HBZ cooperates with JunD to enhance transcription of the human telomerase reverse. | BioMed Central Retrovirology Research HTLV-1 HBZ cooperates with JunD to enhance transcription of the human telomerase reverse transcriptase gene hTERT Anne-Sophie Kuhlmann1 2 3 Julien Villaudy1 2 3 Louis Gazzolo1 2 3 Marc Castellazzi1 2 3 Jean-Michel Mesnard4 and Madeleine Duc Dodon 1 2 3 Address 1Virologie Humaine INSERM-U758 69364 Lyon Cedex 07 France 2Ecole Normale Supérieure de Lyon 69364 Lyon Cedex 07 France 3IFR 128 BioSciences Lyon-Gerland 69364 Lyon Cedex 07 France and 4Laboratoire des Infections Rétrovirales et Signalisation Cellulaire CNRS UM I UMR 5121 IFR122 Institut de Biologie 34960 Cedex 2 Montpellier France Email Anne-Sophie Kuhlmann - Julien Villaudy - Louis Gazzolo - Marc Castellazzi - Jean-Michel Mesnard - Madeleine Duc Dodon - Corresponding author Open Access Published 13 December 2007 Received 18 June 2007 Accepted 13 December 2007 Retrovirology 2007 4 92 doi l 742-4690-4-92 p This article is available from http content 4 1 92 2007 Kuhlmann et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Activation of telomerase is a critical and late event in tumor progression. Thus in patients with adult-T cell leukaemia ATL an HTLV-1 Human T cell Leukaemia virus type 1 -associated disease leukemic cells display a high telomerase activity mainly through transcriptional up-regulation of the human telomerase catalytic subunit hTERT . The HBZ HTLV-1 bZIP protein coded by the minus strand of HTLV-1 genome .
