Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: " Valproic acid and HIV-1 latency: beyond the sound bite. | Retrovirology BioMed Central Commentary Valproic acid and HIV-I latency beyond the sound bite Stephen M Smith Open Access Address Section of Infectious Diseases Department of Medicine Saint Michael s Medical Center and Department of Preventive Medicine and Community Health The New Jersey Medical School Newark New Jersey 07102 USA Email Stephen M Smith - ssmith1824@ Corresponding author Published 19 September 2005 Received 12 September 2005 Accepted 19 September 2005 Retrovirology 2005 2 56 doi 1742-4690-2-56 This article is available from http content 2 1 56 2005 Smith licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract A recent publication in Lancet by Dr. David Margolis and colleagues raised the prospect that HIV infection may be curable. In this pilot study which received much attention from the press Dr. Margolis group found that valproic acid plus enfuvirtide reduces the pool of CD4 T-cells which are latently infected with HIV-1 the so-called viral reservoir. This commentary critically addresses current data on this topic. A recent publication in Lancet 1 has created quite a stir among HIV circles no not those containing 1 or 2-LTRs 2 and the lay press. In a study led by Dr. David Margolis four patients each of whom had undetectable HIV plasma viral loads had enfuvirtide and valproic acid VPA added to their anti-HIV regimens. The researchers measured several parameters with particular interest in the effect of VPA on resting CD4 T-cells latently infected with HIV-1. This pool of cells - often referred to as the viral reservoir - is thought to pose an significant obstacle to HIV eradication. Drs. Finzi Siliciano and colleagues first described these CD4 T-cells that produce .
