Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Duration of salmeterol-induced bronchodilation in mechanically ventilated chronic obstructive pulmonary disease patients: a prospective clinical study. | Available online http content 1 2 6 R140 Research Duration of salmeterol-induced bronchodilation in mechanically ventilated chronic obstructive pulmonary disease patients a prospective clinical study Polychronis Malliotakis Manolis Linardakis George Gavriilidis and Dimitris Georgopoulos Intensive Care Medicine Department University Hospital of Heraklion University of Crete PO Box 1352 71110 Heraklion Crete Greece Corresponding author Dimitris Georgopoulos georgop@ Received 18 Jun 2008 Revisions requested 20 Jul 2008 Revisions received 4 Aug 2008 Accepted 14 Nov 2008 Published 14 Nov 2008 Critical Care 2008 12 R140 doi cc7117 This article is online at http content 12 6 R1 40 2008 Malliotakis et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Delivery of bronchodilators with a metered-dose inhaler MDI and a spacer device in mechanically ventilated patients has become a widespread practice. However except for the short-acting p2-agonist salbutamol the duration of action of other bronchodilators including long-acting p2-agonists delivered with this technique is not well established. The purpose of this study was to examine the duration of bronchodilation induced by the long-acting p2-agonist salmeterol administered with an MDI and a spacer in a group of mechanically ventilated patients with exacerbation of chronic obstructive pulmonary disease COPD . Methods Ten mechanically ventilated patients with acute exacerbation of COPD received four puffs of salmeterol 25 pg puff . Salmeterol was administered with an MDI adapted to the inspiratory limb of the ventilator circuit using an aerosol cloud enhance spacer. Static and dynamic airway pressures minimum
