Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Anti-inflammatory effects of Chinese medicinal herbs on cerebral ischemia. | Su and Hsieh Chinese Medicine 2011 6 26 http content 6 1 26 CHINESE MEDICINE REVIEW Open Access Anti-inflammatory effects of Chinese medicinal herbs on cerebral ischemia Shan-Yu Su1 and Ching-Liang Hsieh1 2 3 Abstracts Recent studies have demonstrated the importance of anti-inflammation including cellular immunity inflammatory mediators reactive oxygen species nitric oxide and several transcriptional factors in the treatment of cerebral ischemia. This article reviews the roles of Chinese medicinal herbs as well as their ingredients in the inflammatory cascade induced by cerebral ischemia. Chinese medicinal herbs exert neuroprotective effects on cerebral ischemia. The effects include inhibiting the activation of microglia decreasing levels of adhesion molecules such as intracellular adhesion molecule-1 attenuating expression of pro-inflammatory cytokines such as interleukin-1b and tumor necrosis factor-a reducing inducible nitric oxide synthase and reactive oxygen species and regulating transcription factors such as nuclear factor-KB. Introduction Activation of multiple inflammatory cascades accounts for the progressing of ischemia stroke 1 . After cerebral ischemia energy depletion and necrotic neuron death in the local ischemic area start the inflammatory cascades. The reperfusion generates reactive oxygen species ROS that induce the production of cytokines and chemokines leading peripheral leukocytes to influx into the cerebral parenchyma and activate endogenous microglia. Then cellular immunity adhesion molecules inflammatory mediators transcriptional factors participate in the inflammatory process. Anti-inflammatory treatment that inhibits specific steps of the inflammatory cascade is a new strategy for improving outcome after ischemia stroke 2-4 . The anti-inflammatory agents including a variety of natural products used in Chinese medicine have been shown to be able to prevent or treat ischemic stroke by decreasing the infarct area and .
