Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: " Morphological instability and cancer invasion: a 'splashing water drop' analogy | Theoretical Biology and Medical Modelling BioMed Central Open Access Morphological instability and cancer invasion a splashing water drop analogy Caterina Guiot1 Pier P Delsanto2 and Thomas S Deisboeck 3 Address 1Dip. Neuroscience and CNISM Università di Torino Italy 2Dip. Fisica Politecnico di Torino Italy and 3Complex Biosystems Modeling Laboratory Harvard-MIT HST Athinoula A. Martinos Center for Biomedical Imaging Massachusetts General Hospital Charlestown MA 02129 USA Email Caterina Guiot - Pier P Delsanto - Thomas S Deisboeck - deisboec@ Corresponding author Published 25 January 2007 Received 27 December 2006 Theoretical Biology and Medical Modelling 2007 4 4 doi 1742-4682-4-4 Accepted 25 January 2007 This article is available from http content 4 1 4 2007 Guiot et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract__ Background Tissue invasion one of the hallmarks of cancer is a major clinical problem. Recent studies suggest that the process of invasion is driven at least in part by a set of physical forces that may be susceptible to mathematical modelling which could have practical clinical value. Model and conclusion We present an analogy between two unrelated instabilities. One is caused by the impact of a drop of water on a solid surface while the other concerns a tumor that develops invasive cellular branches into the surrounding host tissue. In spite of the apparent abstractness of the idea it yields a very practical result . an index that predicts tumor invasion based on a few measurable parameters. We discuss its application .
