Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: " A mathematical model separates quantitatively the cytostatic and cytotoxic effects of a HER2 tyrosine kinase inhibitor | Theoretical Biology and Medical Modelling BioMed Central Research A mathematical model separates quantitatively the cytostatic and cytotoxic effects of a HER2 tyrosine kinase inhibitor Peter Hinow1 4 Shizhen Emily Wang2 4 Carlos L Arteaga2 3 and Glenn F Webb 1 Open Access Address Department of Mathematics Vanderbilt University Nashville TN 37240 USA 2Department of Cancer Biology Vanderbilt University Nashville TN 37232 USA 3Department of Medicine Vanderbilt University Nashville TN 37232 USA and 4These authors contributed equally to this study Email Peter Hinow - Shizhen Emily Wang - Carlos L Arteaga - Glenn F Webb - Corresponding author Published 3 April 2007 Received 18 January 2007 Theoretical Biology and Medical Modelling 2007 4 14 doi 1742-4682-4-14 Accepted 3 April 2007 This article is available from http content 4 1 14 2007 Hinow et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Oncogene signaling is known to deregulate cell proliferation resulting in uncontrolled growth and cellular transformation. Gene amplification and or somatic mutations of the HER2 Neu ErbB2 proto-oncogene occur in approximately 20 of breast cancers. A therapeutic strategy that has been used to block HER2 function is the small molecule tyrosine kinase inhibitor lapatinib. Using human mammary epithelial cells that overexpress HER2 we determined the anti-proliferative effect of lapatinib through measuring the total cell number and analyzing the cell cycle distribution. A mathematical model was used to .
