Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Malignant catatonia due to anti-NMDA-receptor encephalitis in a 17-year-old girl: case report. | Consoli et al. Child and Adolescent Psychiatry and Mental Health 2011 5 15 http content 5 1 15 CHILD ADOLESCENT PSYCHIATRY MENTAL HEALTH CASE REPORT Open Access Malignant catatonia due to anti-NMDA-receptor encephalitis in a 17-year-old girl case report Angèle Consoli1 Karine Ronen1 Isabelle An-Gourfinkel2 Martine Barbeau1 Donata Marra3 1 f H I i o r r lC f oH 11 I 1 I3 Fhci I f l H i fiCi K ir ir it o fir ll 05 DFii lir if iCi K isỉlrci 1H4 Chix icir Rnnn it1 Ahricir i f liHolr it 6 Nathalie Costedoat Ciialuiiieau Delphine Morneiioie Philippe Maksud Olivier Bonnot Adrien Didelot Zahir Amoura3 Marie Vidailhet2 and David Cohen1 Abstract Anti-NMDA-Receptor encephalitis is a severe form of encephalitis that was recently identified in the context of acute neuropsychiatric presentation. Here we describe the case of a 17-year-old girl referred for an acute mania with psychotic features and a clinical picture deteriorated to a catatonic state. Positive diagnosis of anti-NMDA-receptor encephalitis suggested specific treatment. She improved after plasma exchange and immunosuppressive therapy. Post-cognitive sequelae memory impairment disappeared within 2-year follow-up and intensive cognitive rehabilitation. Keywords Anti-NMDA-Receptor encephalitis Adolescence Malignant catatonia Background NMDA receptors are ligand-gated cation channels that play an important role in synaptic plasticity 1 and seem to be implicated in the physiopathology of neuropsychiatric disorders 2 . NMDA receptors are heteromers of NR1 and NR2 subunits A B C or D that bind glycine and glutamate respectively 3 . Both glycine and glutamate must bind for the NMDA receptor to be functional. Anti-NMDA-receptor encephalitis has been recently identified. The antibodies found in anti-NMDA-receptor encephalitis are directed against the NR1 subunit of the NMDA receptor 4 . The clinical syndrome of a paraneoplastic neuropsychiatric disorder associated with ovarian teratoma was first described in .
