Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Thoracic epidural anesthesia in sepsis - is it harmful or protective? | Available online http content 13 5 182 Commentary Thoracic epidural anesthesia in sepsis - is it harmful or protective Christian Mutz1 2 and Dierk A Vagts1 2 1 Department of Anaesthesiology and Intensive Care Medicine Hetzelstift Hospital Neustadt Weinstrasse Stiftstrasse 10 D-67434 Neustadt Weinstrasse Germany 2Department of Anaesthesiology and Intensive Care Medicine University of Rostock Schillingallee 35 D-18057 Rostock Germany Corresponding author Dierk A Vagts Published 16 September 2009 This article is online at http content 13 5 182 2009 BioMed Central Ltd Critical Care 2009 13 182 doi cc8015 See related research by Freise et al. http content 13 4 R116 and Lauer et al. http content 13 4 R109 Abstract Research interest in epidural anesthesia during sepsis has grown over the past years and studies have tried to determine its mechanisms which should theoretically protect organs and reduce morbidity and mortality. However different experimental approaches in different animal models have provided conflicting results over whether epidural anesthesia has protective or harmful effects and whether these alter depending on the phase of sepsis the spread of epidural anesthesia or additional supportive therapies. In the future more standardized research is necessary to integrate the results of all studies which have been published. The hypothesis that a systemic or a regional reduction of sympathetic activity - for example induced by thoracic epidural anesthesia - might have positive effects on the perfusion and oxygenation that is increase them of splanchnic organs like the liver and gut and that reduction of pain improves pulmonary function sounds profound. Although interest in this field of research has been increasing over the past years detailed knowledge about the effects of increased or reduced sympathetic activity on organ perfusion and oxygenation and the mechanisms involved as
