Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Renal dysfunction in chronic liver disease. | Slack et al. Critical Care 2010 14 214 http content 14 2 214 CRITICAL CARE REVIEW L_ Renal dysfunction in chronic liver disease Andy Slack Andrew Yeoman and Julia Wendon This article is one of ten reviews selected from the Yearbook of Intensive Care and Emergency Medicine 2010 Springer Verlag and co-published as a series in Critical Care. Other articles in the series can be found online at http ccforum series yearbook. Further information about the Yearbook of Intensive Care and Emergency Medicine is available from http series 2855. Introduction Acute kidney injury AKI chronic kidney disease and the evaluation of numerous exogenous and endogenous measures of kidney function and injury continue to be the focus of much research in different patient populations. The key reason behind this effort is the well described independent association that small changes in kidney function are strongly linked with increased mortality extending to those with chronic liver disease. The accurate assessment of kidney function and injury is currently affected by the reliance on the measured concentration of serum creatinine which is significantly affected by the degree of cirrhosis hyperbilirubinemia and the nutritional state of the patient. Improved understanding of the pathophysiology of kidney injury and development of more accurate measures of kidney function and injury are necessary to evoke a positive shift in kidney injury diagnosis treatment and outcomes. Furthermore the number of patients with chronic liver disease and chronic kidney disease continues to rise due to the large numbers of individuals worldwide affected by viral hepatitides obesity hypertension and diabetes. Consequently preventative health care messages must be louder and further reaching in order to reverse this trend. Co-existing liver and kidney disease Chronic liver disease and primary liver cancer account for 1 in 40 deaths worldwide with hepatitis B the commonest .
