Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Bench-to-bedside review: Bacterial pneumonia with influenza - pathogenesis and clinical implications. | van der Sluijs et al. Critical Care 2010 14 219 http content 14 2 219 CRITICAL CARE REVIEW L_ Bench-to-bedside review Bacterial pneumonia with influenza - pathogenesis and clinical implications Koenraad F van der Sluijs 1 Tom van der Poll2 René Lutter1 Nicole P Juffermans3 and Marcus J Schultz3 Abstract Seasonal and pandemic influenza are frequently complicated by bacterial infections causing additional hospitalization and mortality. Secondary bacterial respiratory infection can be subdivided into combined viral bacterial pneumonia and post-influenza pneumonia which differ in their pathogenesis. During combined viral bacterial infection the virus the bacterium and the host interact with each other. Post-influenza pneumonia may at least in part be due to resolution of inflammation caused by the primary viral infection. These mechanisms restore tissue homeostasis but greatly impair the host response against unrelated bacterial pathogens. In this review we summarize the underlying mechanisms leading to combined viral bacterial infection or post-influenza pneumonia and highlight important considerations for effective treatment of bacterial pneumonia during and shortly after influenza. Background on influenza pandemics Influenza A virus is one of the most prevalent pathogens causing respiratory illness every winter 1 . These influenza outbreaks are usually associated with mild symptoms such as fever headache sore throat sneezing and nausea accompanied by decreased activity and food intake 2 . Nevertheless influenza virus still accounts for 250 000 to 500 000 deaths each year and this number may increase due to the recently emerged H1N1 pandemic influenza strain 3 . Influenza virus evolves rapidly because of a high mutation rate and may escape acquired immunity 4 . Correspondence kvandersluijs@ departments of Pulmonology and Experimental Immunology Academic Medical Center PO Box 22700 1100 DE Amsterdam The Netherlands Full list of author .
