Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Cytokine profiles of suction pulmonary secretions from children infected with pandemic influenza A(H1N1) 2009. | Kawashima et al. Critical Care 2010 14 411 http content 14 2 411 CRITICAL CARE LETTER L_ Cytokine profiles of suction pulmonary secretions from children infected with pandemic influenza A H1N1 2009 Hisashi Kawashima Soken Go Yasuyo Kashiwagi Yasuyuki Morishima Taro Miura Masanobu Ushio Shigeo Nishimata and Kouji Takekuma See related research by Bermejo-Martin etal. http content 13 6 R201 Uncomplicated influenza in humans is characterized by massive virus replication in respiratory epithelial cells inflammation and an abrupt onset. The novel influenza A H1N1 2009 caused an epidemic of critical illness and some patients rapidly developed severe acute respiratory distress syndrome 1 2 . Van Reeth 3 reviewed growing evidence that the so-called early cytokines produced at the site of infection mediate many of the clinical and pathological manifestations of influenza infection. Of those cytokines Bermejo-Martin and colleagues 4 reported in Critical Care that T-helper 1 Th1 and Th17 hypercytokinemia plays an important role as an early host response in severe pandemic influenza. Evaluating the differences in early immune responses between hospitalized patients with severe pandemic influenza and those with mild disease high systemic levels of IFN-y and a group of mediators involved in the development of the Th17 IL-8 IL-9 IL-17 IL-6 and Th1 TNF-a IL-15 IL-12p70 responses were found exclusively in hospitalized patients. A significant inverse association was found between IL-6 and IL-8 and PaO2 in critical patients. They concluded that severe disease with respiratory involvement is characterized by early secretion of Th17 and Th1 cytokines. We experienced two cases of pandemic influenza A H1N1 2009-associated pneumonia and encephalopathy which were treated under mechanical ventilation. Cytokine analysis of their pulmonary secretions revealed different patterns from previous results Figure 1 . One patient showed no improvement with usual .
