Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Cost-consequence analysis of remifentanil-based analgo-sedation vs. conventional analgesia and sedation for patients on mechanical ventilation in the Netherlands. | Al et al. Critical Care 2010 14 R195 http content 14 6 R195 c CRITICAL CARE RESEARCH Open Access Cost-consequence analysis of remifentanil-based analgo-sedation vs. conventional analgesia and sedation for patients on mechanical ventilation in the Netherlands 1 1 1 2 Maiwenn J Al Leona Hakkaart Siok Swan Tan Jan Bakker Abstract Introduction Hospitals are increasingly forced to consider the economics of technology use. We estimated the incremental cost-consequences of remifentanil-based analgo-sedation RS vs. conventional analgesia and sedation CS in patients requiring mechanical ventilation MV in the intensive care unit ICU using a modelling approach. Methods A Markov model was developed to describe patient flow in the ICU. The hourly probabilities to move from one state to another were derived from UltiSAFE a Dutch clinical study involving ICU patients with an expected MV-time of two to three days requiring analgesia and sedation. Study medication was either CS morphine or fentanyl combined with propofol midazolam or lorazepam or RS remifentanil combined with propofol when required . Study drug costs were derived from the trial whereas all other ICU costs were estimated separately in a Dutch micro-costing study. All costs were measured from the hospital perspective price level of 2006 . Patients were followed in the model for 28 days. We also studied the sub-population where weaning had started within 72 hours. Results The average total 28-day costs were 15 626 with RS versus 17 100 with CS meaning a difference in costs of 1474 95 CI -2163 5110 . The average length-of-stay LOS in the ICU was days in the RS group versus days in the CS group difference 95 CI while the average MV time was days for RS versus days for CS. Similar differences were found in the subgroup analysis. Conclusions Compared to CS RS significantly decreases the overall costs in the ICU. Trial Registration NCT00158873. Introduction The .
