Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Clara cell protein in bronchoalveolar lavage fluid: a predictor of ventilator-associated pneumonia? | Vanspauwen et al. Critical Care 2011 15 R14 http content 15 1 R14 KS CRITICAL CARE RESEARCH Open Access Clara cell protein in bronchoalveolar lavage fluid a predictor of ventilator-associated pneumonia 1 1 1 14 2 Marijke J Vanspauwen Catharina FM Linssen Cathrien A Bruggeman Jan A Jacobs Marjolein Drent Dennis CJJ Bergmans3 Walther NKA van Mook3 Abstract Introduction Clara cell protein 10 CC-10 has been associated with inflammatory and infectious pulmonary diseases. This study evaluates CC-10 concentrations in bronchoalveolar lavage BAL fluid as a potential marker of ventilator-associated pneumonia VAP . Methods Between January 2003 and December 2007 BAL fluid samples obtained from critically ill patients at the intensive care unit of the Maastricht University Medical Centre clinically suspected of having VAP were included. Patients were divided into two groups 1 microbiologically confirmed VAP the VAP group and 2 microbiologically unconfirmed VAP the non-VAP group . The concentration of CC-10 was measured by means of a commercially available enzyme-linked immunosorbent assay kit and retrospective analysis was performed. Areas under the curve of receiver operating characteristic curves were calculated for CC-10 concentrations. Results A total of 196 patients 122 men 74 women were included. A total of 79 40 of 196 cases of suspected VAP were microbiologically confirmed. The median CC-10 concentration in the VAP group was 3 019 ng mL range 282 to 65 546 ng mL versus 2 504 ng mL range 62 to 30 240 ng mL in the non-VAP group P . There was no significant difference in CC-10 concentrations between patients treated with or without corticosteroids P or antibiotic therapy P . The CC-10 concentration did not differ significantly between patients with Gram-positive versus Gram-negative bacteria that caused the VAP P . However CC-10 concentrations did differ significantly between the late-onset VAP group and the non-VAP group. Conclusions The .
