Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Intravenous magnesium sulphate for aneurysmal subarachnoid hemorrhage: an updated systemic review and meta-analysis. | Wong et al. Critical Care 2011 15 R52 http content 15 1 R52 KS CRITICAL CARE RESEARCH Open Access Intravenous magnesium sulphate for aneurysmal subarachnoid hemorrhage an updated systemic review and meta-analysis George KC Wong Ronald Boet2 Wai S Poon Matthew TV Chan3 Tony Gin3 Stephanie CP Ng Benny CY Zee Abstract Introduction Previous meta-analyses of magnesium sulphate infusion in the treatment of aneurysmal subarachnoid hemorrhage SAH have become outdated due to recently published clinical trials. Our aim was thus to perform an up-to-date systemic review and meta-analysis of published data on the use of magnesium sulphate infusion in aneurysmal SAH patients. Methods A systemic review and meta-analysis of the literature was carried out on published randomized controlled clinical trials that investigated the efficacy of magnesium sulphate infusion in aneurysmal SAH patients. The results were analyzed with regard to delayed cerebral ischemia DCI delayed cerebral infarction and favorable neurological outcomes at three and six months. The risks of bias were assessed using the Jadad criteria with a Jadad score 3 indicating a lower such risk. Meta-analyses are presented in terms of relative risk RR with 95 confidence intervals CIs . Results Six eligible studies with 875 patients were reviewed. The pooled RR for DCI was 95 CI to P . That for delayed cerebral infarction was 95 CI to P although this result did not persist if only randomized clinical trials with a lower risk of bias were included RR 95 CI to P . The pooled RR for a favorable outcome at three months was 95 CI to P and that for a favorable outcome at six months was 95 CI to P . Conclusions The present findings do not lend support to a beneficial effect of magnesium sulphate infusion on delayed cerebral infarction. The reduction in DCI and improvement in the clinical outcomes of aneurysmal SAH .
