Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Transcriptional profiling of MnSOD-mediated lifespan extension in Drosophila reveals a species-general network of aging and metabolic genes. | Research Open Access Transcriptional profiling of MnSOD-mediated lifespan extension in Drosophila reveals a species-general network of aging and metabolic genes Christina Curtis Gary N Landis Donna Folk Nancy B Wehr Nicholas Hoe Morris Waskar Diana Abdueva Dmitriy Skvortsov Daniel Ford Allan Luu Ananth Badrinath Rodney L Levine Timothy J Bradley Simon Tavaré and John Tower Addresses Molecular and Computational Biology Program Department of Biological Sciences University of Southern California Los Angeles CA 90089-1340 USA. Department of Ecology and Evolutionary Biology University of California Irvine CA 92717 USA. Laboratory of Biochemistry National Heart Lung and Blood Institute Bethesda MD 20817-6735 USA. Department of Pathology and Laboratory Medicine Childrens Hospital Los Angeles Keck School of Medicine University of Southern California Los Angeles CA 90089-9034 USA. Department of Oncology University of Cambridge Cambridge CB2 2XZ UK. Correspondence John Tower. Email jtower@ Published 9 December 2007 Genome Biology 2007 8 R262 doi gb-2007-8- l2-r262 The electronic version of this article is the complete one and can be found online at http 2007 8 12 R262 Received 23 July 2007 Revised 12 September 2007 Accepted 9 December 2007 2007 Curtis et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Several interventions increase lifespan in model organisms including reduced insulin insulin-like growth factor-like signaling IIS FOXO transcription factor activation dietary restriction and superoxide dismutase SOD over-expression. One question is whether these manipulations function through different mechanisms or whether they intersect on common processes affecting aging. .
