Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học quốc tế đề tài: Quantitative trait loci analysis for leg weaknessrelated traits in a Duroc × Pietrain crossbred population | Laenoi et al. Genetics Selection Evolution 2011 43 13 http content 43 1 13 GSE Ge n et i cs Selection Evolution RESEARCH Open Access Quantitative trait loci analysis for leg weakness-related traits in a Duroc X Pietrain crossbred population 1 11 11 Watchara Laenoi Muhammad Jasim Uddin Mehmet Ulas Cinar Christine GroBe-Brinkhaus Dawit Tesfaye Elisabeth Jonas1 2 Armin M Scholz3 Ernst Tholen1 Christian Looft1 Klaus Wimmers4 Chirawath Phatsara1 5 Heinz Juengst1 Helga Sauerwein1 Manfred Mielenz1 and Karl Schellander1 Abstract Background Leg weakness issues are a great concern for the pig breeding industry especially with regard to animal welfare. Traits associated with leg weakness are partly influenced by the genetic background of the animals but the genetic basis of these traits is not yet fully understood. The aim of this study was to identify quantitative trait loci QTL affecting leg weakness in pigs. Methods Three hundred and ten F2 pigs from a Duroc X Pietrain resource population were genotyped using 82 genetic markers. Front and rear legs and feet scores were based on the standard scoring system. Osteochondrosis lesions were examined histologically at the head and the condylus medialis of the left femur and humerus. Bone mineral density bone mineral content and bone mineral area were measured in the whole ulna and radius bones using dual energy X-ray absorptiometry. A line-cross model was applied to determine QTL regions associated with leg weakness using the QTL Express software. Results Eleven QTL affecting leg weakness were identified on eight autosomes. All QTL reached the 5 chromosome-wide significance level. Three QTL were associated with osteochondrosis on the humerus end two with the fore feet score and two with the rear leg score. QTL on SSC2 and SSC3 influencing bone mineral content and bone mineral density respectively reached the 5 genome-wide significance level. Conclusions Our results confirm previous studies and provide .
