Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: From single cells to whole organisms. | Meeting report From single cells to whole organisms Silke Sperling Address Max Planck Institute for Molecular Genetics Ihnestrasse 73 14195 Berlin Germany. E-mail sperling@ Published 3 January 2006 Genome Biology 2005 6 365 doi gb-2005-6-l3-365 The electronic version of this article is the complete one and can be found online at http 2005 6 13 365 2005 BioMed Central Ltd A report on the European Science Foundation Conference Functional Genomics and Disease Oslo Norway 6-10 September 2005. Functional genomics aims to provide a bridge from the static information in the genome to the related functional properties of the cell tissue or organism. Data on a genome-wide level are generated using a variety of high-throughput technologies and are analyzed using bioinformatics and systemlevel integration. The program of the recent European Science Foundation Conference on functional genomics linked the most promising developments in functional genomics research and technology with their applications and future in biomedicine. Complex genotype-phenotype relationships Considerable effort is currently being made to reveal the relationship between complex genotypes and phenotype for example in looking at the enormous genetic variation that exists in outbred populations such as our own and how it manifests itself in phenotypic variation. One approach to uncovering the molecular basis of common diseases such as cancer and cardiovascular diseases is the correlation of sequence variation among healthy and ill individuals to try and understand how genetic perturbations interact to affect clinical outcome. Analyzing genotype-phenotype relationships in simpler organisms than humans Charlie Boone University of Toronto Canada and Andrew Fraser Wellcome Trust Sanger Institute Cambridge UK reported on global genetic-interaction projects in Saccharomyces cere-visiae and Caenorhabditis elegans that aim to identify overlapping functions and compensatory
