Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Analysis of proteomic profiles and functional properties of human peripheral blood myeloid dendritic cells, monocyte-derived dendritic cells and the dendritic cell-like KG-1 cells reveals distinct characteristics. | Open Access Analysis of proteomic profiles and functional properties of human peripheral blood myeloid dendritic cells monocyte-derived dendritic cells and the dendritic cell-like KG-1 cells reveals distinct characteristics Claire Horlock Farouk Shakib Jafar Mahdavi Nick S Jones Herb F Sewell and Amir M Ghaemmaghami Addresses institute of Infection Immunity and Inflammation School of Molecular Medical Sciences The University of Nottingham Nottingham NG7 2UH UK. Division of Otorhinolaryngology School of Medical and Surgical Sciences The University of Nottingham Nottingham NG7 2UH UK. Correspondence Amir M Ghaemmaghami. Email amg@ Published I March 2007 Genome Biology 2007 8 R30 doi I86 gb-2007-8-3-r30 The electronic version of this article is the complete one and can be found online at http 2007 8 3 R30 Received 2 August 2006 Revised 1 December 2006 Accepted 1 March 2007 2007 Horlock et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Dendritic cells DCs are specialized antigen presenting cells that play a pivotal role in bridging innate and adaptive immune responses. Given the scarcity of peripheral blood myeloid dendritic cells mDCs investigators have used different model systems for studying DC biology. Monocyte-derived dendritic cells moDCs and KG-1 cells are routinely used as mDC models but a thorough comparison of these cells has not yet been carried out particularly in relation to their proteomes. We therefore sought to run a comparative study of the proteomes and functional properties of these cells. Results Despite general similarities between mDCs and the model systems moDCs and KG-1 cells our findings identified some significant differences in the .
