Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: DNA vaccines: designing strategies against parasitic infections | Genetic Vaccines and Therapy BioMed Central Review Open Access DNA vaccines designing strategies against parasitic infections Catherine Ivory and Kris Chadee Address Institute of Parasitology of McGill University Macdonald Campus 21 111 Lakeshore Road Ste. Anne de Bellevue Quebec Canada H9X 3V9 Email Catherine Ivory - cativory@ Kris Chadee - Corresponding author Published 03 December 2004 Received 05 October 2004 Accepted 03 December 2004 Genetic Vaccines and Therapy 2004 2 17 doi 1479-0556-2-17 H This article is available from http content 2 1 17 2004 Ivory and Chadee licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract The complexity of parasitic infections requires novel approaches to vaccine design. The versatility of DNA vaccination provides new perspectives. This review discusses the use of prime-boost immunizations genetic adjuvants multivalent vaccines and codon optimization for optimal DNA vaccine design against parasites. Introduction DNA vaccination was introduced in 1990 by a study that demonstrated the induction of protein expression upon direct intramuscular injection of plasmid DNA in myocytes 1 . DNA vaccines are new types of sub-unit vaccines allowing protein expression in mammalian cells after introduction of plasmid or recombinant viral vectors encoding the selected protective antigen. Protective immunity conferred by DNA vaccines has been shown in many animal models of various diseases including HIV tuberculosis and cancer 2-4 . DNA vaccines induce strong humoral and cellular immunity and have the potential to increase immunogenicity through modifications of the vector or incorporation of adjuvant-like cytokine genes. Successful vaccines .
