Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Developmental stage related patterns of codon usage and genomic GC content: searching for evolutionary fingerprints with models of stem cell differentiation. | Open Access Research Developmental stage related patterns of codon usage and genomic GC content searching for evolutionary fingerprints with models of stem cell differentiation Lichen Ren Ge Gao Dongxin Zhao Mingxiao Ding Jingchu Luo and Hongkui Deng Addresses College of Life Sciences Shanghai Jiao Tong University Shanghai 200240 PR China. Center for Bioinformatics College of Life Sciences National Laboratory of Protein Engineering and Plant Genetics Engineering Peking University Beijing 100871 PR China. Department of Cell Biology and Genetics College of Life Sciences Peking University Beijing 100871 PR China. Correspondence Hongkui Deng. Email hongkui_deng@ Published 12 March 2007 Genome Biology 2007 8 R35 doi 186 gb-2007-8-3-r35 The electronic version of this article is the complete one and can be found online at http 2007 8 3 R35 Received 12 September 2006 Revised 8 January 2007 Accepted 12 March 2007 2007 Ren et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The usage of synonymous codons shows considerable variation among mammalian genes. How and why this usage is non-random are fundamental biological questions and remain controversial. It is also important to explore whether mammalian genes that are selectively expressed at different developmental stages bear different molecular features. Results In two models of mouse stem cell differentiation we established correlations between codon usage and the patterns of gene expression. We found that the optimal codons exhibited variation AT- or GC-ending codons in different cell types within the developmental hierarchy. We also found that genes that were enriched developmental-pivotal genes or specifically expressed .
