Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: The miR-17-5p microRNA is a key regulator of the G1/S phase cell cycle transition. | Open Access Research The miR-17-5p microRNA is a key regulator of the Gl S phase cell cycle transition Nicole Cloonan Mellissa K Brown Anita L Steptoe Shivangi Wani Wei Ling ChanA Alistair RR Forrest Gabriel Kolle Brian Gabrielli and Sean M Grimmond Addresses Institute for Molecular Bioscience The University of Queensland Carmody Road St Lucia 4072 Australia. Diamantina Institute for Cancer Immunology and Metabolic Medicine Princess Alexandra Hospital Ipswich Road Woolloongabba 4102 Australia. Genomic Sciences Center RIKEN Yokohama Institute Yokohama 230-0045 Japan. Correspondence Sean M Grimmond. Email A Deceased Published 14 August 2008 Genome Biology 2008 9 RI27 doi gb-2008-9-8-rI 27 The electronic version of this article is the complete one and can be found online at http 2008 9 8 RI27 Received 25 March 2008 Revised 3 July 2008 Accepted I4 August 2008 2008 Cloonan et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background MicroRNAs are modifiers of gene expression acting to reduce translation through either translational repression or mRNA cleavage. Recently it has been shown that some microRNAs can act to promote or suppress cell transformation with miR-l7-92 described as the first oncogenic microRNA. The association of miR-I7-92 encoded microRNAs with a surprisingly broad range of cancers not only underlines the clinical significance of this locus but also suggests that miR-l7-92 may regulate fundamental biological processes and for these reasons miR-l7-92 has been considered as a therapeutic target. Results In this study we show that miR-I7-92 is a cell cycle regulated locus and ectopic expression of a single microRNA miR-I7-5p is sufficient to drive
