Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Tandem and cryptic amino acid repeats accumulate in disordered regions of proteins. | Open Access Research Tandem and cryptic amino acid repeats accumulate in disordered regions of proteins Michelle Simon and John M Hancock Address Bioinformatics Group MRC Harwell Mammalian Genetics Unit Harwell Science and Innovation Campus Harwell Oxfordshire OX11 0RD UK. Correspondence John M Hancock. Email Published I June 2009 Genome Biology 2009 10 R59 doi gb-2009- I0-6-r59 The electronic version of this article is the complete one and can be found online at http 2009 I0 6 R59 Received I9 March 2009 Accepted I June 2009 2009 Simon and Hancock licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Amino acid repeats AARs are common features of protein sequences. They often evolve rapidly and are involved in a number of human diseases. They also show significant associations with particular Gene Ontology GO functional categories particularly transcription suggesting they play some role in protein function. It has been suggested recently that AARs play a significant role in the evolution of intrinsically unstructured regions IURs of proteins. We investigate the relationship between AAR frequency and evolution and their localization within proteins based on a set of 5 8I5 orthologous proteins from four mammalian human chimpanzee mouse and rat and a bird chicken genome. We consider two classes of AAR tandem repeats and cryptic repeats regions of proteins containing overrepresentations of short amino acid repeats . Results Mammals show very similar repeat frequencies but chicken shows lower frequencies of many of the cryptic repeats common in mammals. Regions flanking tandem AARs evolve more rapidly than the rest of the protein containing the repeat and this .
