Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Elevated risks of death for diabetes mellitus and cardiovascular diseases in Italian AIDS cases. | Serraino et al. AIDS Research and Therapy 2010 7 11 http content 7 1 11 AIDS RESEARCH AND THERAPY SHORT REPORT Open Access Elevated risks of death for diabetes mellitus and cardiovascular diseases in Italian AIDS cases Diego Serraino 1 Silvia Bruzzone2 Antonella Zucchetto1 Barbara Suligoi3 Angela De Paoli1 Simona Pennazza2 Laura Camoni3 Luigino Dal Maso1 Paoli De Paoli4 and Giovanni Rezza3 Abstract After the introduction of highly active antiretroviral therapies HAART an increased incidence of insulin resistance diabetes mellitus DM and cardiovascular diseases has been described. The impact of such conditions on mortality in the post-HAART era has been also assessed in various modes in the literature. In this paper we report on the death risks for DM myocardial infarction and chronic ischemic heart diseases that were investigated among 9662 Italian AIDS cases diagnosed between 1999 and 2005. Death certificates reporting DM myocardial infarction and chronic ischemic heart diseases were reviewed to identify the underlying cause of death and to compare the observed numbers of deaths with the expected ones from the sex- and age-matched general population of Italy. Person-years at risk of death were computed from date of AIDS diagnosis up to date of death or to December 31 2006. Standardized mortality ratios SMR and their 95 confidence intervals CI were computed. DM and cardiovascular diseases were the cause of death for 43 out of 3101 deceased AIDS cases . of all deaths . In comparison with the general population the risks of death were higher for DM 95 CI higher for myocardial infarction 95 CI and for chronic ischemic heart diseases 95 CI . Findings HIV-infected people are at increasing risk of developing several non-AIDS defining illnesses including diabetes mellitus DM and cardiovascular diseases 1-3 . Traditional risk factors such as cigarette smoking ageing obesity and viral co-infections
