Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Trends in reported AIDS defining illnesses (ADIs) among participants in a universal antiretroviral therapy program: an observational study. | Jafari et al. AIDS Research and Therapy 2011 8 31 http content 8 1 31 AIDS RESEARCH AND THERAPY RESEARCH Open Access Trends in reported AIDS defining illnesses ADIs among participants in a universal antiretroviral therapy program an observational study 2 3 2 24 Siavash Jafari Keith Chan Kewan Aboulhosn Benita Yip Viviane D Lima Robert S Hogg Julio Montaner2 4 and David M Moore2 4 Abstract Background We examined trends in AIDS-defining illnesses ADIs among individuals receiving highly active antiretroviral therapy HAART in British Columbia BC Canada to determine whether declines in ADIs could be contributing to previously observed improvements in life-expectancy among HAART patients in BC since 1996. Methods HAART-naive individuals aged 18 years who initiated treatment in BC each of the following timeperiods 1996 - 1998 1999 - 2001 2002 - 2004 2005 - 2007 were included. The proportion of participants with reported ADIs were examined for each time period and trends were analyzed using the Cochran-Armitage Trend Test. Cox proportional hazards models were used to examine factors associated with ADIs. Results A total of 3721 individuals 81 male initiated HAART during the study period. A total of 251 reports of ADIs were received from 214 unique patients. These occurred in a median of 4 months IQR 1-19 months from HAART initiation. The proportion of individuals with a reported ADI did not change significantly from in the earliest time period to in the latest period p for test of trend . There were no significant declines in any specific ADI over the study period. Multivariable Cox models found that individuals initiating HAART during 2002-04 were at an increased risk of ADIs AHR 95 CI in comparison to 1996 - 98 but there were no significant differences in other time periods. Conclusions Trends in reported ADIs among individuals receiving HAART since 1996 in BC do not appear to parallel improvements in .
