Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Structural insights into the function of the core-circadian factor TIMING OF CAB2 EXPRESSION 1 (TOC1). | Journal of Circadian Rhythms BioMed Central Research Structural insights into the function of the core-circadian factor TIMING OF CAB2 EXPRESSION 1 TOC1 Elsebeth Kolmos Heiko Schoof Michael Plumer and Seth J Davis Open Access Address Max Planck Institute for Plant Breeding Research Carl-von-Linné-Weg 10 D-50829 Cologne Germany Email Elsebeth Kolmos - kolmos@ Heiko Schoof - schoof@ Michael Plumer - pluemer@ Seth J Davis - davis@ Corresponding author Published 25 February 2008 Received 23 December 2007 Accepted 25 February 2008 Journal of Circadian Rhythms 2008 6 3 doi 1740-3391-6-3 This article is available from http content 6 1 3 2008 Kolmos et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract__ Background The plant circadian clock has at its core a feedback loop that includes TIMING OF CAB2 EXPRESSION I TOC1 . This protein has an as of yet unknown biochemical activity. It has been noted that the extreme amino-terminus of this protein is distantly related in sequence to response regulators RR and thus TOC1 is a member of the so-called pseudo response regulator PRR family. As well the extreme carboxy-terminus has a small sequence stretch related to the other PRRs and CONSTANS CO -like proteins and this peptide stretch has been termed the CCT for CONSTANS CONSTANS-LIKE TOC1 domain. Methods To extend further our understanding of the TOC1 protein we performed a ROSETTA structural prediction on TOC1 orthologues from four plant species. Phylogenetic interpretations assisted in model construction. Results From our models we suggest that TOCI
