Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Exploring the potential effect of Ocimum sanctum in vincristine-induced neuropathic pain in rats. | Kaur et al. Journal of Brachial Plexus and Peripheral Nerve Injury 2010 5 3 http content 5 1 3 JOURNAL OF BRACHIAL PLEXUS AND PERIPHERAL NERVE INJURY RESEARCH ARTICLE Open Access Exploring the potential effect of Ocimum sanctum in vincristine-induced neuropathic pain in rats Gurpreet Kaur Amteshwar Singh Jaggi Nirmal Singh Abstract The present study was designed to investigate the ameliorative potential of Ocimum sanctum and its saponin rich fraction in vincristine-induced peripheral neuropathic pain in rats. Peripheral neuropathy was induced in rats by administration of vincristine sulfate 50 gg kg . for 10 consecutive days. The mechanical hyperalgesia cold allo-dynia paw heat hyperalgesia and cold tail hyperalgesia were assessed by performing the pinprick acetone hot plate and cold tail immersion tests respectively. Biochemically the tissue thio-barbituric acid reactive species TBARS super-oxide anion content markers of oxidative stress and total calcium levels were measured. Vincristine administration was associated with the development of mechanical hyperalgesia cold allodynia heat and cold hyperalgesia. Furthermore vincristine administration was also associated with an increase in oxidative stress and calcium levels. However administration of Ocimum sanctum 100 and 200 mg kg . and its saponin rich fraction 100 and 200 mg kg . for 14 days significantly attenuated vincristine-induced neuropathic pain along with decrease in oxidative stress and calcium levels. It may be concluded that Ocimum sanctum has ameliorative potential in attenuating chemotherapy induced-painful neuropathic state which may be attributed to decrease in oxidative stress and calcium levels. Furthermore saponin rich fraction of Ocimum sanctum may be responsible for its noted beneficial effect in neuropathic pain in rats. Introduction Neuropathic pain has been described as the most terrible of all tortures which a nerve wound may inflict 1 . Despite progress in the .
