Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Plasma levels of leptin and soluble leptin receptor and polymorphisms of leptin gene -18G A and leptin receptor genes K109R and Q223R, in survivors of childhood acute lymphoblastic leukemia | Skoczen et al. Journal of Experimental Clinical Cancer Research 2011 30 64 http content 30 1 64 Journal of Experimental Clinical Cancer Research RESEARCH Open Access Plasma levels of leptin and soluble leptin receptor and polymorphisms of leptin gene -18G A and leptin receptor genes K109R and Q223R in survivors of childhood acute lymphoblastic leukemia Szymon Skoczen1 Przemyslaw J Tomasik 3 Miroslaw Bik-Multanowski4 Marcin Surmiak5 Walentyna Balwierz2 Jacek J Pietrzyk4 Krystyna Sztefko3 Jolanta Gozdzik1 Danuta Galicka-LataJa6 and Wojciech Strojny2 Abstract Background Approximately 20 of children and adolescents in Europe are overweight. Survivors of pediatric acute lymphoblastic leukemia ALL are at increased risk of overweight and obesity. The purpose of this study was to assess leptin and leptin soluble receptor levels as well as polymorphisms of selected genes in survivors of pediatric ALL and the influence of chemo- and radiotherapy on development of overweight in the context of leptin regulation. Methods Eighty two patients 55 males of median age years m years M years were included in the study. The ALL therapy was conducted according to modified Berlin-Frankfurt-Munster BFM n 69 regimen or New York n 13 regimen. In 38 of patients cranial radiotherapy CRT was used in median dose of m 14Gy M 24Gy . Median age at diagnosis was m 1 year M years and median time from completion of ALL treatment was years m year M years . Patients with BMI 85 percentile were classified as overweight. Correlation of plasma levels of leptin and leptin soluble receptor and polymorphisms of leptin gene -18G A leptin receptor genes K109R and Q223R and the overweight status were analyzed in relation to gender intensity of chemotherapy high intensity vs. standard intensity regimens and to the use of CRT. Results Significant differences of leptin levels in patients treated with and without CRT both in the entire study group -
