Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: CYP1A1 MspI and exon7 gene polymorphisms and lung cancer risk: An updated meta-analysis and review | Zhan et al. Journal of Experimental Clinical Cancer Research 2011 30 99 http content 30 1 99 Journal of Experimental Clinical Cancer Research RESEARCH Open Access CYP1A1 MspI and exon7 gene polymorphisms and lung cancer risk An updated meta-analysis and review Ping Zhan1t Qin Wang2t Qian Qian1 Shu-Zhen Wei3 and Li-Ke Yu1 Abstract Background Many studies have examined the association between the CYP1A1 MspI and exon 7 gene polymorphisms and lung cancer risk in various populations but their results have been inconsistent. Methods To assess this relationship more precisely a meta-analysis and review were performed. The PubMed Embase Web of Science and CNKI database was searched for case-control studies published up to June 2010. Data were extracted and pooled odds ratios OR with 95 confidence intervals CI were calculated. Results Ultimately 64 studies comprising 18 397 subjects from 49 case-control studies of the MspI genotype and 18 518 patients from 40 case-control studies of the exon 7 genotype were included. A significantly elevated lung cancer risk was associated with 2 MspI genotype variants for type C vs Type A OR 95 CI for types B and C combined vs Type A OR 95 CI in overall population. In the stratified analysis a significant association was found in Asians Caucasians lung SCC lung AC and Male population not in mixed population lung SCLC and Female population. However inconsistent results were observed for CYP1A1 exon7 in our meta-analysis two variants of the exon 7 polymorphism were associated with a significantly higher risk for lung cancer for Val Val vs Ile Ile OR 95 CI for Ile Val Val Val vs Ile Ile OR 95 CI in overall population. In the stratified analysis a significant assocation was found in Asians Caucasians lung SCC and Female population not in mixed population lung AD lung SCLC and Male population. Additionally a significant association was found in smoker population and not
