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Báo cáo y học: "Early reduction in painful physical symptoms is associated with improvements in long-term depression outcomes in patients treated with duloxetine"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Early reduction in painful physical symptoms is associated with improvements in long-term depression outcomes in patients treated with duloxetine | Schneider et al. BMC Psychiatry 2011 11 150 http www.biomedcentral.com 1471-244X 11 150 BMC Psychiatry RESEARCH ARTICLE Open Access Early reduction in painful physical symptoms is associated with improvements in long-term depression outcomes in patients treated with duloxetine 1 2 3 1 4 1 Edith Schneider Michael Linden Harald Weigmann Thomas Wagner Deborah Quail Hans-Peter Hundemer and Ulrich Hegerl5 Abstract Background To investigate the association of the change of painful physical symptoms PPS after 4 weeks with the 6-month treatment outcomes of depressive symptoms in patients treated with duloxetine in clinical practice. Methods Multicenter prospective 6-month non-interventional study in adult outpatients with a depressive episode and starting treatment with duloxetine. Depression severity was assessed by the clinician Inventory for Depressive Symptomatology IDS-C and patient Kurz-Skala Stimmung Aktivierung KUSTA . Somatic symptoms and PPS were assessed using the patient-rated Somatic Symptom Inventory SSI and visual analog scales VAS for pain items. Association of change in PPS with outcomes of depressive symptoms was analyzed based on mean KUSTA scores mean of items mood activity tension relaxation sleep and achievement of a 50 reduction in the total IDS-C score after 6 months using linear and logistic regression models respectively. Results Of the 4 517 patients enrolled mean age 52.2 years 71.8 female 3 320 patients 73.5 completed the study. 80 of the patients had moderate to severe overall pain VAS 30 mm at baseline. A 50 VAS overall pain reduction after 4 weeks was associated with a 13.32 points higher mean KUSTA score after 6 months and a 50 pain reduction after 2 weeks with a 6.33 points improvement. No unexpected safety signals were detected in this naturalistic study. Conclusion Pain reduction after 2 and 4 weeks can be used to estimate outcomes of long-term treatment with duloxetine. PPS associated with depression have a potential role in predicting