Đang chuẩn bị liên kết để tải về tài liệu:
báo cáo hóa học: " Induction of serine racemase expression and D-serine release from microglia by amyloid β-peptide"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Induction of serine racemase expression and D-serine release from microglia by amyloid β-peptide | Journal of Neuroinflammation BioMed Central Research Open Access Induction of serine racemase expression and D-serine release from microglia by amyloid p-peptide Sheng-Zhou Wu1 Angela M Bodies2 Mandy M Porter2 W Sue T Griffin1 2 4 Anthony S Basile3 and Steven W Barger 1 2 4 Address Department of Neurobiology Developmental Sciences University of Arkansas for Medical Sciences Little Rock Arkansas USA 2Department of Geriatrics University of Arkansas for Medical Sciences Little Rock Arkansas USA 3DOV Pharmaceutical Inc. Hackensack New Jersey USA and 4Geriatric Research Education and Clinical Center Central Arkansas Veterans Healthcare System Little Rock Arkansas USA Email Sheng-Zhou Wu - wushengzhou@uams.edu Angela M Bodles - bodlesangela@uams.edu Mandy M Porter - portermandym@uams.edu W Sue T Griffin - griffinsuet@uams.edu Anthony S Basile - abasile@dovpharm.com Steven W Barger - sbarger@uams.edu Corresponding author Published 20 April 2004 Received 22 March 2004 Journal of Neuroinflammation 2004 1 2 Accepted 20 April 2004 This article is available from http www.jneuroinflammation.eom content 1 1 2 2004 Wu et al licensee BioMed Central Ltd. This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract Background Roles for excitotoxicity and inflammation in Alzheimer s disease have been hypothesized. Proinflammatory stimuli including amyloid P-peptide AP elicit a release of glutamate from microglia. We tested the possibility that a coagonist at the NMDA class of glutamate receptors D-serine could respond similarly. Methods Cultured microglial cells were exposed to AP. The culture medium was assayed for levels of D-serine by HPLC and for effects on calcium and survival on primary cultures of rat hippocampal neurons. Microglial cell lysates were examined for the levels of mRNA and protein for serine racemase the enzyme that .