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Báo cáo hóa học: " New Method to Prepare Mitomycin C Loaded PLA-Nanoparticles with High Drug Entrapment Efficiency"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: New Method to Prepare Mitomycin C Loaded PLA-Nanoparticles with High Drug Entrapment Efficiency | Nanoscale Res Lett 2009 4 732-737 DOI 10.1007 S11671-009-9312-Z NANO EXPRESS New Method to Prepare Mitomycin C Loaded PLA-Nanoparticles with High Drug Entrapment Efficiency Zhenqing Hou Heng Wei Qian Wang Qian Sun Chunxiao Zhou Chuanming Zhan Xiaolong Tang Qiqing Zhang Received 10 February 2009 Accepted 2 April 2009 Published online 21 April 2009 to the authors 2009 Abstract The classical utilized double emulsion solvent diffusion technique for encapsulating water soluble Mitomycin C MMC in PLA nanoparticles suffers from low encapsulation efficiency because of the drug rapid partitioning to the external aqueous phase. In this paper MMC loaded PLA nanoparticles were prepared by a new single emulsion solvent evaporation method in which soybean phosphatidylcholine SPC was employed to improve the liposolubility of MMC by formation of MMC-SPC complex. Four main influential factors based on the results of a single-factor test namely PLA molecular weight ratio of PLA to SPC wt wt and MMC to SPC wt wt volume ratio of oil phase to water phase were evaluated using an orthogonal design with respect to drug entrapment efficiency. The drug release study was performed in pH 7.2 PBS at 37 C with drug analysis using UV vis spectrometer at 365 nm. MMC-PLA particles prepared by classical method were used as comparison. The formulated MMC-SPC-PLA nanoparticles under optimized condition are found to be relatively uniform in size 594 nm with up to 94.8 of drug entrapment efficiency compared to 6.44 m of PLA-MMC microparticles with 34.5 of drug Z. Hou H. Wei Q. Wang Q. Sun C. Zhou C. Zhan X. Tang Q. Zhang H Research Center of Biomedical Engineering of Xiamen University Material College of Xiamen University Xiamen 361005 China e-mail zhangqiq@xmu.edu.cn Z. Hou e-mail houzhenqing@xmu.edu.cn Q. Zhang Chinese Academy of Medical Sciences Peking Union Medical College Institute of Biomedical Engineering Tianjin 300192 China entrapment efficiency. The release of MMC shows biphasic with an .