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Báo cáo Y học: The analysis of the fine specificity of celiac disease antibodies using tissue transglutaminase fragments

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Celiacdisease isan intestinalmalabsorptioncharacterizedby an intolerance to cereal proteins accompanied by immuno-logical responses to dietary gliadins and an autoantigen located in the endomysium. The latter has been identified as the enzyme tissue transglutaminase which belongs to a family of enzymes that catalyze protein cross-linking reac-tions and is constitutivelyexpressed inmany tissues aswell as being activated during apoptosis.

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