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Structural differences of amyloid-β fibrils revealed by antibodies from phage display

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Beside neurofibrillary tangles, amyloid plaques are the major histological hallmarks of Alzheimer’s disease (AD) being composed of aggregated fibrils of β-amyloid (Aβ). During the underlying fibrillogenic pathway, starting from a surplus of soluble Aβ and leading to mature fibrils, multiple conformations of this peptide appear, including oligomers of various shapes and sizes. | Structural differences of amyloid-β fibrils revealed by antibodies from phage display

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