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TNF-α - mediated peripheral and central inflammation are associated with increased incidence of PND in acute postoperative pain

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Acute postoperative pain plays an important role in the perioperative neurocognitive disorders (PND). The pathogenesis of PND is still unknown, but it is generally believed that peripheral and central nervous system inflammation play an important role, and acute postoperative pain is also thought to aggravate postoperative inflammatory response. |